Between over 100,000 dead Iraqis and six million dead Jews?

Where do you draw the line?  Does the sentence "What's the difference between three thousand dead New Yorkers and millions of dead Native Americans" strike you as a reasonable statement? If not then again I ask, where should the line be drawn?

You might also notice that I explicitly included the extermination of Native Americans as one of those cases where one can sensibly argue that they are comparable to the Shoah. At the same time the two events played out in a very different manner so one can compare and contrast away. For example, the Native Americans were subject to a centuries long persecution that was much more intense than that suffered by the European Jews prior to the Nazis. Another example - there was no concerted, all encompassing period of extermination of Native Americans comparable to what happened to the Jews in 1941-5.

(A couple commenters seem to have a problem with my use of the term 'Holocaust' in its common colloquial sense of the extermination of European Jews by the Nazis, perhaps a substitution of the term 'Shoah' will placate them)