Sorry, I misspoke regarding the population figure.
In respect to the removal of nukes, I was not suggesting that nukes in the hands of irresponsible leadership was preferable to their removal (be they eastern, western, American or Pakistani), but rather that the removal did not solve the problem so much as redefine it.
The occupation of Afghanistan does become a very different sort of problem with an openly hostile Pakistan.  If that kind of problem is met by someone of George Bush's temperament and subtlety, then I think we can anticipate many new and less than entertaining developments.
And yes, many folk in the region would be happy to see Pakistan without nukes, but I don't think that will stop them from hating America more for their interference.  We don't need to anticipate "rational" reactions -- that would be a bit much to ask.