But none of us choose or control our own history

We certainly do not choose the circumstances into which we are born.  Worse, the development of our brains is guided for years by our parents, who are, after all, only doing the best they can. But at a certain point we can become aware of these factors and then we have the ability to choose how we react and respond to that situation.  Therein lies our own opportunity and responsibility.

"It is not necessary to have hope in order to persevere."