From the above-cited Wikipedia entry:

Sex, exercise, eating, and risk taking generally result in the release of endorphins

So opoid receptor antagonists could conceivably be used not only in anti-obesity therapy, but also to curb dumbass risk-taking behavior, say, of financial traders.

Wouldn't it be interesting if a financial regulator were to require all persons involved financialization to take Nalmafene twice a day?

The fact is that what we're experiencing right now is a top-down disaster. -Paul Krugman