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BIG Pharma CEOs to offer Johnson experimental Covid-19 treatments | The Guardian |

Donald Trump has said he asked US pharmaceutical companies working on experimental coronavirus drugs to approach Boris Johnson's doctors and offer their help, after it emerged that the British prime minister was in intensive care.

In an evening press briefing, Trump did not name the companies or the drugs, but earlier in the day he held a conference about therapeutic drugs with the heads of four US pharmaceutical and biotech companies: Amgen, Genetech, Gilead, and Regeneron.

Trump has consistently promoted the anti-malarial drug hydroxychloroquine in combination with an antibiotic azithromycin, as a "game-changer" in the battle with coronavirus, although his own health officials have cautioned that there is no proof they are effective.

My earlier diary - Crisis In Leadership

Related reading ...

The Trumpian French Doctor Behind the Chloroquine Hype | Slate |

by Oui on Tue Apr 7th, 2020 at 07:45:25 AM EST
atm, the funniest "explainer" since this bogus pHARMa story broke (omitting UNKNOWN potions of favorite market makers) most illiterate, litigious nation on planet into WHO.int, FDA kitchen-chemist consultants is at Politico.

What you need to know about the malaria drugs Trump keeps touting. There still are no approved treatments for the coronavirus.

4. There have already been shortages

The FDA added versions

Chloroquine phosphate must be administered orally.

To request chloroquine phosphate under Emergency Use Authorization (EUA): Contact your Local or State Health Department Health care providers must submit a report on all medication errors, ALL SERIOUS ADVERSE EVENTS, and CLINICAL OUTCOMES related to chloroquine phosphate. See specific reporting instructions below.

The optimal dosing and duration of treatment for COVID-19 is unknown.

of chloroquine and hydroxychloroquine to its shortage list last week after prescriptions spiked as much 7,000 percent in March. The hype has already made it difficult for people with lupus and arthritis to get the drugs, said David Karp, a Texas doctor and president-elect of the American College of Rheumatology, the providers who largely treat those patients.
[..]
5. There's worry the chloroquine craze could crowd out trials of other potential cures
[...]
Gilead, maker of one experimental treatment -- the antiviral drug remdesivir [AND IT'S A FLOORWAX BWAH!] -- has attempted to shift away from giving it to patients outside of trials as it races for answers. The biotech company said this weekend that it currently has enough doses for roughly 140,000 people.

"versions" of generic compounds

by Cat on Tue Apr 7th, 2020 at 04:53:25 PM EST
[ Parent ]
more off-label hijinks... out of Africa

Aaron Miller et al, Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study (pre-print) 28 Mar

Here we propose that national differences in COVID-19 impact could be partially explained by the different national policies respect to Bacillus Calmette-Guerin (BCG) childhood vaccination. BCG vaccination has been reported to offer broad protection to respiratory infections. We compared large number of countries BCG vaccination policies with the morbidity and mortality for COVID-19. We found that countries without universal policies of BCG vaccination (Italy, Nederland, USA) have been more severely affected compared to countries with universal and long-standing BCG policies.
RT | 'Striking' evidence emerges that TB vaccine may be effective against Covid-19 -- countries that use it have TEN TIMES fewer cases
In this study, 178 countries were included, of which 131 have national programmes of BCG vaccination, 21 do not, and 26 have an unknown status. Interestingly, the USA and Italy are among the rich, developed countries to have never had a universal BCG programme. Spain also does not have one, but their Iberian neighbours Portugal do, and they had only 209 deaths at the time of writing. The UK ran a modest vaccination programme that ended in 2005.
Science | Can a century-old TB vaccine steel the immune system against the new coronavirus?
A team in the Netherlands will kick off the first of the trials this week. They will recruit 1000 health care workers in eight Dutch hospitals who will either receive the vaccine, called bacillus Calmette-Guérin (BCG), or a placebo. ...BCG may also increase the ability of the immune system to fight off pathogens other than the TB bacterium, according to clinical and observational studies published over several decades by Danish researchers Peter Aaby and Christine Stabell Benn, who live and work in Guinea-Bissau. They concluded the vaccine prevents about 30% of infections with any known pathogen, including viruses, in the first year after it's given.
archived Tue Feb 18th, 2020
by Cat on Tue Apr 7th, 2020 at 07:14:32 PM EST
[ Parent ]
Der Drumpfenfuehrer has been promoting it because he owns a piece of Sanofi, which makes Panequil.
by rifek on Wed Apr 8th, 2020 at 03:29:15 PM EST
[ Parent ]
Where is Don Rumsfeld?
by Cat on Wed Apr 8th, 2020 at 03:34:54 PM EST
[ Parent ]

[X] miracle cure
But questions remain about the quick recovery. Was it the drug that lead to the improvement? Or would the man have gotten better the next day anyway?

Susan Kane said remdesivir appeared to work quickly for her husband, too.

"On the very next day, he said: 'You know, I think it's lifting. I think I'm starting to feel better,'" she recalled.

Chris Kane is now home and, although he still gets winded easily, he is improving, according to his wife.

"We are 100,000 percent convinced that the remdesivir turned things around for him," Susan Kane said.

Because remdesivir is now officially in clinical trials at Providence Regional Medical Center, Kane's doctors declined an interview with NBC News, as they are unable to comment on the efficacy of the drug before results are made public.

by Cat on Wed Apr 8th, 2020 at 11:16:47 PM EST
[ Parent ]
Tamil Nadu?

'The history of public debt is full of irony. It rarely follows our ideas of order and justice.' Thomas Piketty
by melo (melometa4(at)gmail.com) on Thu Apr 9th, 2020 at 08:12:50 AM EST
[ Parent ]
Out of chaos ... be very specific who gets the contracts ... Iraq War - Katrina Disaster - CoV-2 Pandemic ...

Best supervisor for contracts, the President's son-in-law Jared Kushner. Did the trick with Middle-East peace settlement ... MORE settlements and recognition Israeli superiority. The Jewish State appreciates President Trump ... plaque beyond plaque  .etc, etc.

"You scratch my back, I'll scratch your back."

by Oui on Wed Apr 8th, 2020 at 07:46:59 PM EST
[ Parent ]
by Oui on Wed Apr 8th, 2020 at 11:19:55 PM EST
[ Parent ]

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